Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair

Saturation mutagenesis(1,2) – coupled to an appropriate biological assay – represents a fundamental means of achieving a high-resolution understanding of regulatory(3) and protein-coding(4) nucleic acid sequences of interest. However, mutagenized sequences introduced in trans on episomes or via rand...

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Detalles Bibliográficos
Autores principales: Findlay, Gregory M., Boyle, Evan A., Hause, Ronald J., Klein, Jason, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156553/
https://www.ncbi.nlm.nih.gov/pubmed/25141179
http://dx.doi.org/10.1038/nature13695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156553/
https://www.ncbi.nlm.nih.gov/pubmed/25141179
http://dx.doi.org/10.1038/nature13695

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