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Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair
Saturation mutagenesis(1,2) – coupled to an appropriate biological assay – represents a fundamental means of achieving a high-resolution understanding of regulatory(3) and protein-coding(4) nucleic acid sequences of interest. However, mutagenized sequences introduced in trans on episomes or via rand...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156553/ https://www.ncbi.nlm.nih.gov/pubmed/25141179 http://dx.doi.org/10.1038/nature13695 |