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Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis
BACKGROUND: Exocytosis of sperm’s single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the extracellular milieu and continues with the synthesis of cAMP and the activation of its target Epac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156617/ https://www.ncbi.nlm.nih.gov/pubmed/25159528 http://dx.doi.org/10.1186/s12964-014-0043-0 |