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Amyloid-Associated Activity Contributes to the Severity and Toxicity of a Prion Phenotype

The self-assembly of alternative conformations of normal proteins into amyloid aggregates has been implicated in both the acquisition of new functions and in the appearance and progression of disease. However, while these amyloidogenic pathways are linked to the emergence of new phenotypes, numerous...

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Detalles Bibliográficos
Autores principales: Pezza, John A., Villali, Janice, Sindi, Suzanne S., Serio, Tricia R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156856/
https://www.ncbi.nlm.nih.gov/pubmed/25023996
http://dx.doi.org/10.1038/ncomms5384