SCM-198 inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-кB pathways

BACKGROUND: Neuroinflammation mediated by overactivated microglia plays a key role in many neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, we investigated for the first time the anti-neuroinflammatory effects and possible mechanisms of SCM-198 (an alkaloid extracted fr...

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Detalles Bibliográficos
Autores principales: Hong, Zhen-Yi, Shi, Xue-Ru, Zhu, Kai, Wu, Ting-Ting, Zhu, Yi-Zhun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156960/
https://www.ncbi.nlm.nih.gov/pubmed/25134526
http://dx.doi.org/10.1186/s12974-014-0147-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156960/
https://www.ncbi.nlm.nih.gov/pubmed/25134526
http://dx.doi.org/10.1186/s12974-014-0147-x

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