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SCM-198 inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-кB pathways

BACKGROUND: Neuroinflammation mediated by overactivated microglia plays a key role in many neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, we investigated for the first time the anti-neuroinflammatory effects and possible mechanisms of SCM-198 (an alkaloid extracted fr...

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Detalles Bibliográficos
Autores principales:	Hong, Zhen-Yi, Shi, Xue-Ru, Zhu, Kai, Wu, Ting-Ting, Zhu, Yi-Zhun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156960/ https://www.ncbi.nlm.nih.gov/pubmed/25134526 http://dx.doi.org/10.1186/s12974-014-0147-x

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