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Evaluation of CYP2C9 Activity in Rats: Use of Tolbutamide Alone and in Combined with Bupropion

A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was aimed on the influence of bupropion on...

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Detalles Bibliográficos
Autores principales: Qiu, Xiangjun, Song, Jijun, Yuan, Hongchang, Hou, Yi, Pan, Xiaofeng, Xu, Ren-ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157039/
https://www.ncbi.nlm.nih.gov/pubmed/25237359