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Chemical conversion of cisplatin and carboplatin with histidine in a model protein crystallized under sodium iodide conditions
Cisplatin and carboplatin are platinum anticancer agents that are used to treat a variety of cancers. Previous X-ray crystallographic studies of carboplatin binding to histidine in hen egg-white lysozyme (HEWL) showed a partial chemical conversion of carboplatin to cisplatin owing to the high sodium...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Union of Crystallography
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157406/ https://www.ncbi.nlm.nih.gov/pubmed/25195879 http://dx.doi.org/10.1107/S2053230X14013995 |