Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone

Poly(ADP-ribose) polymerases 1 and 2 (PARP1 and PARP2), which are involved in DNA damage response, are targets of anticancer therapeutics. BMN 673 is a novel PARP1/2 inhibitor with substantially increased PARP-mediated tumor cytotoxicity and is now in later-stage clinical development for BRCA-defici...

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Detalles Bibliográficos
Autores principales: Aoyagi-Scharber, Mika, Gardberg, Anna S., Yip, Bryan K., Wang, Bing, Shen, Yuqiao, Fitzpatrick, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Structural Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157409/
https://www.ncbi.nlm.nih.gov/pubmed/25195882
http://dx.doi.org/10.1107/S2053230X14015088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157409/
https://www.ncbi.nlm.nih.gov/pubmed/25195882
http://dx.doi.org/10.1107/S2053230X14015088

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