Orthogonal functionalisation of α-helix mimetics

α-Helix mediated protein–protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using ‘click’ chemistry. The effect is shown...

Descripción completa

Detalles Bibliográficos
Autores principales: Barnard, Anna, Long, Kérya, Yeo, David J., Miles, Jennifer A., Azzarito, Valeria, Burslem, George M., Prabhakaran, Panchami, A. Edwards, Thomas, Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157654/
https://www.ncbi.nlm.nih.gov/pubmed/25065821
http://dx.doi.org/10.1039/c4ob00915k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157654/
https://www.ncbi.nlm.nih.gov/pubmed/25065821
http://dx.doi.org/10.1039/c4ob00915k

Ejemplares similares