Chromatin Accessibility Mapping Identifies Mediators of Basal Transcription and Retinoid-Induced Repression of OTX2 in Medulloblastoma

Despite an emerging understanding of the genetic alterations giving rise to various tumors, the mechanisms whereby most oncogenes are overexpressed remain unclear. Here we have utilized an integrated approach of genomewide regulatory element mapping via DNase-seq followed by conventional reporter as...

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Detalles Bibliográficos
Autores principales: Wortham, Matthew, Guo, Changcun, Zhang, Monica, Song, Lingyun, Lee, Bum-Kyu, Iyer, Vishwanath R., Furey, Terrence S., Crawford, Gregory E., Yan, Hai, He, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157845/
https://www.ncbi.nlm.nih.gov/pubmed/25198066
http://dx.doi.org/10.1371/journal.pone.0107156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157845/
https://www.ncbi.nlm.nih.gov/pubmed/25198066
http://dx.doi.org/10.1371/journal.pone.0107156

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