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Microglia P2Y(6) receptors mediate nitric oxide release and astrocyte apoptosis

BACKGROUND: During cerebral inflammation uracil nucleotides leak to the extracellular medium and activate glial pyrimidine receptors contributing to the development of a reactive phenotype. Chronically activated microglia acquire an anti-inflammatory phenotype that favors neuronal differentiation, b...

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Detalles Bibliográficos
Autores principales: Quintas, Clara, Pinho, Diana, Pereira, Clara, Saraiva, Lucília, Gonçalves, Jorge, Queiroz, Glória
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158093/
https://www.ncbi.nlm.nih.gov/pubmed/25178395
http://dx.doi.org/10.1186/s12974-014-0141-3