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Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

The climbing fiber input to Purkinje cells acts as a teaching signal by triggering a massive influx of dendritic calcium that marks the occurrence of instructive stimuli during cerebellar learning. Here, we challenge the view that these calcium spikes are all-or-none and only signal whether the inst...

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Detalles Bibliográficos
Autores principales: Najafi, Farzaneh, Giovannucci, Andrea, Wang, Samuel S-H, Medina, Javier F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158287/
https://www.ncbi.nlm.nih.gov/pubmed/25205669
http://dx.doi.org/10.7554/eLife.03663