Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing

Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, we developed a whole-genome and exome single cell sequencing approach called Nuc-Seq that utilizes G2/M nuclei to achieve 91% mean coverage...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Waters, Jill, Leung, Marco L., Unruh, Anna, Roh, Whijae, Shi, Xiuqing, Chen, Ken, Scheet, Paul, Vattathil, Selina, Liang, Han, Multani, Asha, Zhang, Hong, Zhao, Rui, Michor, Franziska, Meric-Bernstam, Funda, Navin, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158312/
https://www.ncbi.nlm.nih.gov/pubmed/25079324
http://dx.doi.org/10.1038/nature13600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158312/
https://www.ncbi.nlm.nih.gov/pubmed/25079324
http://dx.doi.org/10.1038/nature13600

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