Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy

There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zhonghua, Li, Shengliang, Liang, Zibin, Zhao, Yan, Zhang, Yulin, Yang, Yaqi, Wang, Minjuan, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Neurodegenerative Disease and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158703/
https://www.ncbi.nlm.nih.gov/pubmed/25206630
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.33.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158703/
https://www.ncbi.nlm.nih.gov/pubmed/25206630
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.33.003

Ejemplares similares