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Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy
There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1,...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158703/ https://www.ncbi.nlm.nih.gov/pubmed/25206630 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.33.003 |