Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

Excision of uracil introduced into the immunoglobulin loci by AID is central to antibody diversification. While predominantly carried out by the UNG uracil‐DNA glycosylase as reflected by deficiency in immunoglobulin class switching in Ung(−/−) mice, the deficiency is incomplete, as evidenced by the...

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Detalles Bibliográficos
Autores principales: Dingler, Felix A., Kemmerich, Kristin, Neuberger, Michael S., Rada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-VCH 2014
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158878/
https://www.ncbi.nlm.nih.gov/pubmed/24771041
http://dx.doi.org/10.1002/eji.201444482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158878/
https://www.ncbi.nlm.nih.gov/pubmed/24771041
http://dx.doi.org/10.1002/eji.201444482

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