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Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

AMPK is known to be activated by oxidative stress. Addition of glucose oxidase to cells generates H(2)O(2) at a constant rate that is opposed by enzymic degradation, providing a good model for physiological oxidative stress. AMPK activation by glucose oxidase correlated with increases in cellular AM...

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Detalles Bibliográficos
Autores principales: Auciello, F. Romana, Ross, Fiona A., Ikematsu, Naoko, Hardie, D. Grahame
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158911/
https://www.ncbi.nlm.nih.gov/pubmed/25084564
http://dx.doi.org/10.1016/j.febslet.2014.07.025