Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells

Dickkopf-related protein 3 (DKK3) is an antagonist of Wnt ligand activity. Reduced DKK3 expression has been reported in various types of cancers, but its functions and related molecular mechanisms in breast tumorigenesis remain unclear. We examined the expression and promoter methylation of DKK3 in...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiang, Tingxiu, Li, Lili, Yin, Xuedong, Zhong, Lan, Peng, Weiyan, Qiu, Zhu, Ren, Guosheng, Tao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159020/
https://www.ncbi.nlm.nih.gov/pubmed/23890219
http://dx.doi.org/10.1111/jcmm.12099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159020/
https://www.ncbi.nlm.nih.gov/pubmed/23890219
http://dx.doi.org/10.1111/jcmm.12099

Ejemplares similares