Structural and Dynamic Characterization of Polymerase κ’s Minor Groove Lesion Processing Reveals How Adduct Topology Impacts Fidelity

[Image: see text] DNA lesion bypass polymerases process different lesions with varying fidelities, but the structural, dynamic, and mechanistic origins of this phenomenon remain poorly understood. Human DNA polymerase κ (Polκ), a member of the Y family of lesion bypass polymerases, is specialized to...

Descripción completa

Detalles Bibliográficos
Autores principales: Lior-Hoffmann, Lee, Ding, Shuang, Geacintov, Nicholas E., Zhang, Yingkai, Broyde, Suse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159208/
https://www.ncbi.nlm.nih.gov/pubmed/25148552
http://dx.doi.org/10.1021/bi5007964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159208/
https://www.ncbi.nlm.nih.gov/pubmed/25148552
http://dx.doi.org/10.1021/bi5007964

Ejemplares similares