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Structural and Dynamic Characterization of Polymerase κ’s Minor Groove Lesion Processing Reveals How Adduct Topology Impacts Fidelity

[Image: see text] DNA lesion bypass polymerases process different lesions with varying fidelities, but the structural, dynamic, and mechanistic origins of this phenomenon remain poorly understood. Human DNA polymerase κ (Polκ), a member of the Y family of lesion bypass polymerases, is specialized to...

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Detalles Bibliográficos
Autores principales:	Lior-Hoffmann, Lee, Ding, Shuang, Geacintov, Nicholas E., Zhang, Yingkai, Broyde, Suse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159208/ https://www.ncbi.nlm.nih.gov/pubmed/25148552 http://dx.doi.org/10.1021/bi5007964

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