Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition

[Image: see text] With current therapies becoming less efficacious due to increased drug resistance, new inhibitors of both bacterial and malarial targets are desperately needed. The recently discovered methylerythritol phosphate (MEP) pathway for isoprenoid synthesis provides novel targets for the...

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Detalles Bibliográficos
Autores principales: Blachly, Patrick G., Sandala, Gregory M., Giammona, Debra Ann, Liu, Tiqing, Bashford, Donald, McCammon, J. Andrew, Noodleman, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159220/
https://www.ncbi.nlm.nih.gov/pubmed/25221444
http://dx.doi.org/10.1021/ct5005214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159220/
https://www.ncbi.nlm.nih.gov/pubmed/25221444
http://dx.doi.org/10.1021/ct5005214

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