Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity

The Siah1 and Siah2 E3 ubiquitin ligases play an important role in diverse signaling pathways and have been shown to be deregulated in cancer. The human Siah1 and Siah2 isoforms share high sequence similarity but possess contrary roles in cancer, with Siah1 more often acting as a tumor suppressor wh...

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Detalles Bibliográficos
Autores principales: Gopalsamy, Anupriya, Hagen, Thilo, Swaminathan, Kunchithapadam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159269/
https://www.ncbi.nlm.nih.gov/pubmed/25202994
http://dx.doi.org/10.1371/journal.pone.0106547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159269/
https://www.ncbi.nlm.nih.gov/pubmed/25202994
http://dx.doi.org/10.1371/journal.pone.0106547

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