Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 may play a role in cold hypersensitivity and hyperal...

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Detalles Bibliográficos
Autores principales: Miller, Silke, Rao, Sara, Wang, Weiya, Liu, Hantao, Wang, Judy, Gavva, Narender R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159296/
https://www.ncbi.nlm.nih.gov/pubmed/25203266
http://dx.doi.org/10.1371/journal.pone.0107151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159296/
https://www.ncbi.nlm.nih.gov/pubmed/25203266
http://dx.doi.org/10.1371/journal.pone.0107151

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