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Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation
The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 may play a role in cold hypersensitivity and hyperal...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159296/ https://www.ncbi.nlm.nih.gov/pubmed/25203266 http://dx.doi.org/10.1371/journal.pone.0107151 |