A Native Chemical Ligation Handle that Enables the Synthesis of Advanced Activity-Based Probes: Diubiquitin as a Case Study

We present the development of a native chemical ligation handle that also functions as a masked electrophile that can be liberated during synthesis when required. This handle can thus be used for the synthesis of complex activity-based probes. We describe the use of this handle in the generation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mulder, Monique P C, El Oualid, Farid, ter Beek, Jarno, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159580/
https://www.ncbi.nlm.nih.gov/pubmed/24623714
http://dx.doi.org/10.1002/cbic.201402012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159580/
https://www.ncbi.nlm.nih.gov/pubmed/24623714
http://dx.doi.org/10.1002/cbic.201402012

Ejemplares similares