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Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model
Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer’s disease (AD), however reducing Aβ production failed to relieve the symptoms of AD patients. Here we report a high GABA (γ-aminobutyric acid) content in reactive astrocytes in the dentate gyrus (DG) of a mouse model for...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159602/ https://www.ncbi.nlm.nih.gov/pubmed/24923909 http://dx.doi.org/10.1038/ncomms5159 |