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Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model

Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer’s disease (AD), however reducing Aβ production failed to relieve the symptoms of AD patients. Here we report a high GABA (γ-aminobutyric acid) content in reactive astrocytes in the dentate gyrus (DG) of a mouse model for...

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Detalles Bibliográficos
Autores principales:	Wu, Zheng, Guo, Ziyuan, Gearing, Marla, Chen, Gong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159602/ https://www.ncbi.nlm.nih.gov/pubmed/24923909 http://dx.doi.org/10.1038/ncomms5159

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