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Localization of MLH3 at the Centrosomes

Mutations in human DNA mismatch repair (MMR) genes are commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MLH1 protein heterodimerizes with PMS2, PMS1, and MLH3 to form MutLα, MutLβ, and MutLγ, respectively. We reported recently stable expression of GFP-linked MLH3 in human...

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Detalles Bibliográficos
Autores principales: Roesner, Lennart M., Mielke, Christian, Faehnrich, Silke, Merkhoffer, Yvonne, Dittmar, Kurt E. J., Drexler, Hans G., Dirks, Wilhelm G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159832/
https://www.ncbi.nlm.nih.gov/pubmed/25116689
http://dx.doi.org/10.3390/ijms150813932