Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice

CDK5 is a member of the cyclin-dependent kinase family with diverse functions in both the developing and mature nervous system. The inappropriate activation of CDK5 due to the proteolytic release of the activator fragment p25 from the membrane contributes to the formation of neurofibrillary tangles...

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Detalles Bibliográficos
Autores principales: Castro-Alvarez, John F., Uribe-Arias, S. Alejandro, Kosik, Kenneth S., Cardona-Gómez, Gloria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159979/
https://www.ncbi.nlm.nih.gov/pubmed/25309427
http://dx.doi.org/10.3389/fnagi.2014.00243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159979/
https://www.ncbi.nlm.nih.gov/pubmed/25309427
http://dx.doi.org/10.3389/fnagi.2014.00243

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