Activation of Cre Recombinase Alone Can Induce Complete Tumor Regression

The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediate...

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Detalles Bibliográficos
Autores principales: Li, Yulin, Choi, Peter S., Casey, Stephanie C., Felsher, Dean W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160265/
https://www.ncbi.nlm.nih.gov/pubmed/25208064
http://dx.doi.org/10.1371/journal.pone.0107589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160265/
https://www.ncbi.nlm.nih.gov/pubmed/25208064
http://dx.doi.org/10.1371/journal.pone.0107589

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