From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination

[Image: see text] A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman’s chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butan...

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Autores principales: Oldenhuis, Nathan J., Dong, Vy M., Guan, Zhibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160272/
https://www.ncbi.nlm.nih.gov/pubmed/25170560
http://dx.doi.org/10.1021/ja5058482
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author Oldenhuis, Nathan J.
Dong, Vy M.
Guan, Zhibin
author_facet Oldenhuis, Nathan J.
Dong, Vy M.
Guan, Zhibin
author_sort Oldenhuis, Nathan J.
collection PubMed
description [Image: see text] A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman’s chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.
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spelling pubmed-41602722015-08-29 From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination Oldenhuis, Nathan J. Dong, Vy M. Guan, Zhibin J Am Chem Soc [Image: see text] A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman’s chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr. American Chemical Society 2014-08-29 2014-09-10 /pmc/articles/PMC4160272/ /pubmed/25170560 http://dx.doi.org/10.1021/ja5058482 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Oldenhuis, Nathan J.
Dong, Vy M.
Guan, Zhibin
From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title_full From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title_fullStr From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title_full_unstemmed From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title_short From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
title_sort from racemic alcohols to enantiopure amines: ru-catalyzed diastereoselective amination
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160272/
https://www.ncbi.nlm.nih.gov/pubmed/25170560
http://dx.doi.org/10.1021/ja5058482
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AT dongvym fromracemicalcoholstoenantiopureaminesrucatalyzeddiastereoselectiveamination
AT guanzhibin fromracemicalcoholstoenantiopureaminesrucatalyzeddiastereoselectiveamination

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