Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

[Image: see text] Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of...

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Detalles Bibliográficos
Autores principales: Krishnan, Shyam, Miller, Rand M., Tian, Boxue, Mullins, R. Dyche, Jacobson, Matthew P., Taunton, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160273/
https://www.ncbi.nlm.nih.gov/pubmed/25153195
http://dx.doi.org/10.1021/ja505194w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160273/
https://www.ncbi.nlm.nih.gov/pubmed/25153195
http://dx.doi.org/10.1021/ja505194w

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