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Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis
[Image: see text] Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160273/ https://www.ncbi.nlm.nih.gov/pubmed/25153195 http://dx.doi.org/10.1021/ja505194w |