Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode)...

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Detalles Bibliográficos
Autores principales: Eder, Alexandra, Hansen, Arne, Uebeler, June, Schulze, Thomas, Neuber, Christiane, Schaaf, Sebastian, Yuan, Lei, Christ, Torsten, Vos, Marc A., Eschenhagen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160570/
https://www.ncbi.nlm.nih.gov/pubmed/25209140
http://dx.doi.org/10.1007/s00395-014-0436-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160570/
https://www.ncbi.nlm.nih.gov/pubmed/25209140
http://dx.doi.org/10.1007/s00395-014-0436-7

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