Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis

Il1rn(−/−) mice spontaneously develop arthritis and aortitis by an autoimmune mechanism and also develop dermatitis by an autoinflammatory mechanism. Here, we show that Rag2(−/−)Il1rn(−/−) mice develop spontaneous colitis with high mortality, making a contrast to the suppression of arthritis in thes...

Descripción completa

Detalles Bibliográficos
Autores principales: Akitsu, Aoi, Kakuta, Shigeru, Saijo, Shinobu, Iwakura, Yoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2014
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160983/
https://www.ncbi.nlm.nih.gov/pubmed/24770649
http://dx.doi.org/10.1538/expanim.63.235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160983/
https://www.ncbi.nlm.nih.gov/pubmed/24770649
http://dx.doi.org/10.1538/expanim.63.235

Ejemplares similares