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Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis

Il1rn(−/−) mice spontaneously develop arthritis and aortitis by an autoimmune mechanism and also develop dermatitis by an autoinflammatory mechanism. Here, we show that Rag2(−/−)Il1rn(−/−) mice develop spontaneous colitis with high mortality, making a contrast to the suppression of arthritis in thes...

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Detalles Bibliográficos
Autores principales:	Akitsu, Aoi, Kakuta, Shigeru, Saijo, Shinobu, Iwakura, Yoichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Association for Laboratory Animal Science 2014
Materias:	Original
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160983/ https://www.ncbi.nlm.nih.gov/pubmed/24770649 http://dx.doi.org/10.1538/expanim.63.235

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