Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

[Image: see text] Novel substituted pteridine-derived inhibitors of monocarboxylate transporter 1 (MCT1), an emerging target for cancer therapy, are reported. The activity of these compounds as inhibitors of lactate transport was confirmed using a (14)C-lactate transport assay, and their potency aga...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Yang, Chunying, Doherty, Joanne R., Roush, William R., Cleveland, John L., Bannister, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161152/
https://www.ncbi.nlm.nih.gov/pubmed/25068893
http://dx.doi.org/10.1021/jm500640x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161152/
https://www.ncbi.nlm.nih.gov/pubmed/25068893
http://dx.doi.org/10.1021/jm500640x

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