Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents

[Image: see text] To block the metabolically labile sites of novel tubulin inhibitors targeting the colchicine binding site based on SMART, ABI, and PAT templates, we have designed, synthesized, and biologically tested three focused sets of new derivatives with modifications at the carbonyl linker,...

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Detalles Bibliográficos
Autores principales: Lu, Yan, Chen, Jianjun, Wang, Jin, Li, Chien-Ming, Ahn, Sunjoo, Barrett, Christina M., Dalton, James T., Li, Wei, Miller, Duane D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161160/
https://www.ncbi.nlm.nih.gov/pubmed/25122533
http://dx.doi.org/10.1021/jm500764v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161160/
https://www.ncbi.nlm.nih.gov/pubmed/25122533
http://dx.doi.org/10.1021/jm500764v

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