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Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
[Image: see text] To block the metabolically labile sites of novel tubulin inhibitors targeting the colchicine binding site based on SMART, ABI, and PAT templates, we have designed, synthesized, and biologically tested three focused sets of new derivatives with modifications at the carbonyl linker,...
Autores principales: | Lu, Yan, Chen, Jianjun, Wang, Jin, Li, Chien-Ming, Ahn, Sunjoo, Barrett, Christina M., Dalton, James T., Li, Wei, Miller, Duane D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161160/ https://www.ncbi.nlm.nih.gov/pubmed/25122533 http://dx.doi.org/10.1021/jm500764v |
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