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Promiscuous and Adaptable Enzymes Fill “Holes” in the Tetrahydrofolate Pathway in Chlamydia Species

Folates are tripartite molecules comprising pterin, para-aminobenzoate (PABA), and glutamate moieties, which are essential cofactors involved in DNA and amino acid synthesis. The obligately intracellular Chlamydia species have lost several biosynthetic pathways for essential nutrients which they can...

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Detalles Bibliográficos
Autores principales: Adams, Nancy E., Thiaville, Jennifer J., Proestos, James, Juárez-Vázquez, Ana L., McCoy, Andrea J., Barona-Gómez, Francisco, Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie, Maurelli, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161248/
https://www.ncbi.nlm.nih.gov/pubmed/25006229
http://dx.doi.org/10.1128/mBio.01378-14