A Mycobacterium tuberculosis Cytochrome bd Oxidase Mutant Is Hypersensitive to Bedaquiline

The new medicinal compound bedaquiline (BDQ) kills Mycobacterium tuberculosis by inhibiting F(1)F(o)-ATP synthase. BDQ is bacteriostatic for 4 to 7 days and kills relatively slowly compared to other frontline tuberculosis (TB) drugs. Here we show that killing with BDQ can be improved significantly b...

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Detalles Bibliográficos
Autores principales: Berney, Michael, Hartman, Travis E., Jacobs, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161257/
https://www.ncbi.nlm.nih.gov/pubmed/25028424
http://dx.doi.org/10.1128/mBio.01275-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161257/
https://www.ncbi.nlm.nih.gov/pubmed/25028424
http://dx.doi.org/10.1128/mBio.01275-14

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