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A Mycobacterium tuberculosis Cytochrome bd Oxidase Mutant Is Hypersensitive to Bedaquiline

The new medicinal compound bedaquiline (BDQ) kills Mycobacterium tuberculosis by inhibiting F(1)F(o)-ATP synthase. BDQ is bacteriostatic for 4 to 7 days and kills relatively slowly compared to other frontline tuberculosis (TB) drugs. Here we show that killing with BDQ can be improved significantly b...

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Detalles Bibliográficos
Autores principales:	Berney, Michael, Hartman, Travis E., Jacobs, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2014
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161257/ https://www.ncbi.nlm.nih.gov/pubmed/25028424 http://dx.doi.org/10.1128/mBio.01275-14

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