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STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity
Dendritic cells (DCs) are a critical player in immune responses, linking innate and adaptive immunity. We show here that DC-specific deletion of the STAT5 was not critical for development, but was required for type-2, but not type-1, allergic responses in both the skin and lung. Loss of STAT5 in DCs...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161284/ https://www.ncbi.nlm.nih.gov/pubmed/23435120 http://dx.doi.org/10.1038/ni.2541 |
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author | Bell, Bryan D. Kitajima, Masayuki Larson, Ryan P. Stoklasek, Thomas A. Dang, Kristen Sakamoto, Kazuhito Wagner, Kay-Uwe Reizis, Boris Hennighausen, Lothar Ziegler, Steven F. |
author_facet | Bell, Bryan D. Kitajima, Masayuki Larson, Ryan P. Stoklasek, Thomas A. Dang, Kristen Sakamoto, Kazuhito Wagner, Kay-Uwe Reizis, Boris Hennighausen, Lothar Ziegler, Steven F. |
author_sort | Bell, Bryan D. |
collection | PubMed |
description | Dendritic cells (DCs) are a critical player in immune responses, linking innate and adaptive immunity. We show here that DC-specific deletion of the STAT5 was not critical for development, but was required for type-2, but not type-1, allergic responses in both the skin and lung. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of costimulatory molecules and chemokine production. Furthermore, type-2 responses in mice with DC-specific loss of STAT5resembled those seen in TSLPR-deficient mice. These results show that the TSLP- STAT5 axis in DCs is a critical component for the promotion of type-2 immunity at barrier surfaces. |
format | Online Article Text |
id | pubmed-4161284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-41612842014-09-11 STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity Bell, Bryan D. Kitajima, Masayuki Larson, Ryan P. Stoklasek, Thomas A. Dang, Kristen Sakamoto, Kazuhito Wagner, Kay-Uwe Reizis, Boris Hennighausen, Lothar Ziegler, Steven F. Nat Immunol Article Dendritic cells (DCs) are a critical player in immune responses, linking innate and adaptive immunity. We show here that DC-specific deletion of the STAT5 was not critical for development, but was required for type-2, but not type-1, allergic responses in both the skin and lung. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of costimulatory molecules and chemokine production. Furthermore, type-2 responses in mice with DC-specific loss of STAT5resembled those seen in TSLPR-deficient mice. These results show that the TSLP- STAT5 axis in DCs is a critical component for the promotion of type-2 immunity at barrier surfaces. 2013-02-24 2013-04 /pmc/articles/PMC4161284/ /pubmed/23435120 http://dx.doi.org/10.1038/ni.2541 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Bell, Bryan D. Kitajima, Masayuki Larson, Ryan P. Stoklasek, Thomas A. Dang, Kristen Sakamoto, Kazuhito Wagner, Kay-Uwe Reizis, Boris Hennighausen, Lothar Ziegler, Steven F. STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title | STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title_full | STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title_fullStr | STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title_full_unstemmed | STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title_short | STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity |
title_sort | stat5 is critical in dendritic cells for development of t(h)2- but not t(h)1-dependent immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161284/ https://www.ncbi.nlm.nih.gov/pubmed/23435120 http://dx.doi.org/10.1038/ni.2541 |
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