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PTEN Hopping on the Cell Membrane Is Regulated via a Positively-Charged C2 Domain
PTEN, a tumor suppressor that is frequently mutated in a wide spectrum of cancers, exerts PI(3,4,5)P(3) phosphatase activities that are regulated by its dynamic shuttling between the membrane and cytoplasm. Direct observation of PTEN in the interfacial environment can offer quantitative information...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161299/ https://www.ncbi.nlm.nih.gov/pubmed/25211206 http://dx.doi.org/10.1371/journal.pcbi.1003817 |