Positive Selection and Multiple Losses of the LINE-1-Derived L1TD1 Gene in Mammals Suggest a Dual Role in Genome Defense and Pluripotency

Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity to ‘domesticate’ retroelement genes for their own purpose, leading to important innovations in genome defense and placentation. While many su...

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Detalles Bibliográficos
Autores principales: McLaughlin, Richard N., Young, Janet M., Yang, Lei, Neme, Rafik, Wichman, Holly A., Malik, Harmit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161310/
https://www.ncbi.nlm.nih.gov/pubmed/25211013
http://dx.doi.org/10.1371/journal.pgen.1004531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161310/
https://www.ncbi.nlm.nih.gov/pubmed/25211013
http://dx.doi.org/10.1371/journal.pgen.1004531

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