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IL-10 and NOS2 Modulate Antigen-Specific Reactivity and Nerve Infiltration by T Cells in Experimental Leprosy

BACKGROUND: Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance o...

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Detalles Bibliográficos
Autores principales: Hagge, Deanna A., Scollard, David M., Ray, Nashone A., Marks, Vilma T., Deming, Angelina T., Spencer, John S., Adams, Linda B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161319/
https://www.ncbi.nlm.nih.gov/pubmed/25210773
http://dx.doi.org/10.1371/journal.pntd.0003149