Incomplete Deletion of IL-4Rα by LysM(Cre) Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rα(flox/delta)LysM(Cre) mice almost completely lose IL-4Rα function, a large...

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Detalles Bibliográficos
Autores principales: Vannella, Kevin M., Barron, Luke, Borthwick, Lee A., Kindrachuk, Kristen N., Narasimhan, Prakash Babu, Hart, Kevin M., Thompson, Robert W., White, Sandra, Cheever, Allen W., Ramalingam, Thirumalai R., Wynn, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161449/
https://www.ncbi.nlm.nih.gov/pubmed/25211233
http://dx.doi.org/10.1371/journal.ppat.1004372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161449/
https://www.ncbi.nlm.nih.gov/pubmed/25211233
http://dx.doi.org/10.1371/journal.ppat.1004372

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