Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity

The central event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)) into the disease-associated, transmissible form (PrP(Sc)). PrP(C) is a sialoglycoprotein that contains two conserved N-glycosylation sites. Among the key parameters that cont...

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Detalles Bibliográficos
Autores principales: Katorcha, Elizaveta, Makarava, Natallia, Savtchenko, Regina, d′Azzo, Alessandra, Baskakov, Ilia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161476/
https://www.ncbi.nlm.nih.gov/pubmed/25211026
http://dx.doi.org/10.1371/journal.ppat.1004366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161476/
https://www.ncbi.nlm.nih.gov/pubmed/25211026
http://dx.doi.org/10.1371/journal.ppat.1004366

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