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Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity
The central event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)) into the disease-associated, transmissible form (PrP(Sc)). PrP(C) is a sialoglycoprotein that contains two conserved N-glycosylation sites. Among the key parameters that cont...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161476/ https://www.ncbi.nlm.nih.gov/pubmed/25211026 http://dx.doi.org/10.1371/journal.ppat.1004366 |